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Subject: General Question
00_Chem_AJB    6/1/2008 5:03:04 PM
Why is our nation affraid of nuclear power and GM crops?
 
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Armchair Private       6/2/2008 9:01:06 AM
I'd argue that the UK is no more or less scared of these two things than most other western nations, though the US has been far more accepting of GM crops from what I can tell from this side of the Atlantic. This is, perhaps, balanced, or out weighed by the UKs far more accepting line on genetic manipulation of people... or at least embryos etc. In fact we probably have some of the more permissive laws in the west on that issue.

I think that as the level of science and technological understanding has decreased in the public arena, and in the education system, increasingly fewer and fewer people are equipped to make informed judgements on these matters. I'd cite the broardsheets as an example of how low science reporting is. Ben Goldacre in the Guardian holds that paper to account nearly as frequently as the Daily Wail.

Perhaps the difference is that people see GM and Nuclear as directly impacting them, where as messing around with the inside of cell nuclei to make 'cybrids' or whatever is one step removed and done only by the people in white coats.



 
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00_Chem_AJB       6/2/2008 12:34:33 PM
Indeed, there is a slipping trend in science education over here. What started me asking this question was an article I read on the BBC website, and it explained how the environmental fascists demonised GM crops saying they would have an adverse effect on us and the environment, and I'm sure from your point of view it hasn't. The only problem with GM crops is the monopoly held by the supplier, which farmers feel will limit their farming to just what the suppiler wants. I don't under stand how we are able to use genetic engineering to help create medicine to cure our sick yet they take up arms when use genetic engineering to help feed our hungry. 
 
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Wicked Chinchilla       6/2/2008 1:04:33 PM
Can't answer for Nuclear Power, but being in the biological sciences I can possibly give you an answer related to some people's reluctance to GM food. 
 
 I am neither a proponent of GM nor an opponent of GM.  The best seed/food/product should be used regardless of where it came from in whatever situation.  If the natural species is better at growing in lets say a temperate environment, use it.  However, if GM is better in arid/dry regions use that.  Thus, I am pretty much impartial on the matter.
 
There are several arguments I have heard against GM food.  I do not know specifically of their validity, just reciting what I have heard and read from various places.  I am going to explain the legitimate criticisms first. 
 
Reason One: SAFETY
When gene theory was first discovered and flourished and people really started messing with genetics it was generally believed that one gene = one trait protein/function/trait (I am going to substitute the word "allele" here from now on for ease of typing).  It has come to be known, and largely by accident, that one gene does NOT necessarily mean one allele.  Multiple genes could be used for one allele and just as easily one gene could significantly effect multiple alleles.  This brings into question GM's safety.  It is one thing to cross pollenate/cross bread various crops "naturally."  A potentially harmful trait would, most likely, not be reproductively successful in the cross breading and be quashed by a safe product.  When you start messing with individual genes in a lab and then cross them over to the field you can never be absolutely certain of what you get.  Biological systems, and especially genetics, are insanely convulated and interrelated.  Even when a biologist is "certain" of something, he/she never really is %100 sure because there is always that one time when something went wrong for no apparant reason. 
 
So that long paragraph states that there is a fear that GM crops could potentially bring harmful effects to us and we would not know until too late.  This is mostly a long-term fear as everything is tested.  Short term effects like a new toxin in wheat or what not would be detected and the product thrown out.  In comparison, a small animal protein or something that could transfer from the ingested wheat to our genetic code and cause some harm to the functioning of an organ over time could easily not be detected (note, thats not based off of anything, just a random example).
 
2. Reason Two: EFFICACY
I know of at least one study that has been published recently which shows a GM crop compared to its wild-type originator.  In every metric the wild-type seed was superior despite the GM crops supposed superiority.  This wasnt a failed seed, it was a marketed product supposedly better than the original.  Many people wonder why go through the added cost of obtaining this GM seed when the originals are superior. 
 
3.  Reason Three: ECONOMICS
The way GM seed works in the state is you buy it every year and then plant it.  Doesnt sound like much, but with natural seed the farmer simply retains some of his crop for replanting.  There is no need to rebuy seed every, single, year because after your harvest your set for next year.  Thus, while some GM products are cheaper than their natural cousins (I dont mean "Organic Food" either) on the whole they are more expensive because Farmer John must rebuy his seed every growing season.
 
Those are three legitmate reasons for people to object to GM.  Its all down to cost-benefits really.  For many GM products the benefits do not supercede their costs either real (Efficacy/Economics) or potential (genetic damage, etc.).
 
Of course, there is always your stupid asswhole who says we are interfering with God/Allah/Random Deity, but that argument isnt worth the breath used to expel it.  No, not because you shouldn't believe that, you can believe what you want.  The argument is absolutely dumb because we have been interfering with Gods will since the first farmer crossbread his tall, but pest vulnerable wheat with his short, but pest resilient wheat to yield a moderately tall, moderately pest resilient wheat.
 
So their are some reasons why some people are reluctant to make the jump to GM.
 
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Herald12345       6/2/2008 1:37:25 PM
Reason One: SAFETY
When gene theory was first discovered and flourished and people really started messing with genetics it was generally believed that one gene = one trait protein/function/trait (I am going to substitute the word "allele" here from now on for ease of typing).  It has come to be known, and largely by accident, that one gene does NOT necessarily mean one allele.  Multiple genes could be used for one allele and just as easily one gene could significantly effect multiple alleles.  This brings into question GM's safety.  It is one thing to cross pollenate/cross bread various crops "naturally."  A potentially harmful trait would, most likely, not be reproductively successful in the cross breading and be quashed by a safe product.  When you start messing with individual genes in a lab and then cross them over to the field you can never be absolutely certain of what you get.  Biological systems, and especially genetics, are insanely convulated and interrelated.  Even when a biologist is "certain" of something, he/she never really is %100 sure because there is always that one time when something went wrong for no apparent reason

That is good and sufficient in my opinion to be exceedingly cautious when you start monkeying [deliberate choice of word] with food animals' alleles.

I'm not even sure that plants are safe in this context as experimental subjects.

Its a statistical fear I personally intuit-based on Murphy's standard principle.

Herald

 
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Wicked Chinchilla       6/2/2008 2:13:16 PM
Indeed.  I would not put my full backing behind GM products unless it was on a per-seed basis after numerous long-term trials.  Genetics is stupidly complex.  Genetic codes of plants are also generally larger than animals (odd eh?) and filled with genetic detritus.  You never know what might activate some of that ancient DNA thats partial or, for the moment, non-functional.  Just think, every virus that ever infects you has the potential of implanting itself into your genetic code.  Some of those can get into your gametes which means you WILL pass some of that genetic code to your offspring.  Mulitply this millions of years and you will see why genes are such a pain in the ass to predict.  The degree of information contained in them is absolutely enormous especially when you factor in the stuff that appears non-functional.  Mutations can activate genes, disable genes, change function, add new functions and so on and so forth.  I do not believe that we should stop research out of fear, but I dont approve of the rapid pace of GM utilization in the U.S. given the lack of significant long-range testing.  The possibilities are both highly encouraging and highly disquieting. 
 
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DragonReborn       6/2/2008 4:10:44 PM

I'd argue that the UK is no more or less scared of these two things than most other western nations, though the US has been far more accepting of GM crops from what I can tell from this side of the Atlantic. This is, perhaps, balanced, or out weighed by the UKs far more accepting line on genetic manipulation of people... or at least embryos etc. In fact we probably have some of the more permissive laws in the west on that issue.

I think that as the level of science and technological understanding has decreased in the public arena, and in the education system, increasingly fewer and fewer people are equipped to make informed judgments on these matters. I'd cite the broadsheet's as an example of how low science reporting is. Ben Goldacre in the Guardian holds that paper to account nearly as frequently as the Daily Wail.

Perhaps the difference is that people see GM and Nuclear as directly impacting them, where as messing around with the inside of cell nuclei to make 'cybrids' or whatever is one step removed and done only by the people in white coats.



Slightly off topic, but how advanced are the Chinese in genetics, specifically manipulation of empryos. They have huge amounts of students studying all across the West. I always thought that a nation that has implemented a one child policy and has a theology based upon genetic Han superiority would be particularly interested in enhancing the genetic make-up of its people?!!

 
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Wicked Chinchilla       6/2/2008 6:15:46 PM
While I dont know of course about their black projects or if they even have black projects that are genetically oriented most of genetics is purely open source.  Since it started out as a pure science any discovery of note was published pretty quickly.  

As convoluted as genetics is the basic science behind it is rather straightforward.  Its a bit like chess: learning to play is one thing, becoming an expert is quite another.  Genetic manipulation of human DNA is possible now.  Unintended consequences and what happens behind these changes are what is unknown and harmful.  Right now all we can do is fumble with the building blocks.  We cannot create the DNA from scratch, the egg from scratch, grow the egg, etc.  As I said before with what genes actually govern, we have determined to an amazing extent what SOME genes do.  But we do not know what all genes do.  Nor do we know in how many processes they are all involved or their role in these processes.  Take a look at the genetic variants that predispose people to cancer for a taste of the complexity involved.  

What you might be wondering about also is cloning.  We have not figured out how to actually "clone" people or anything for that matter.  On the news when they speak of "cloning" goats or sheep or what not its not cloning as is pictured or talked about in movies.  It resembles artificial insemination more than movie cloning.  I read that article and the other cloning articles a good while ago so the details escape me.  However, my best description is that they take an egg from a female sheep then extract the DNA from it.  Adult DNA from the host sheep is then inserted into the egg.  The sheep is then inseminated with this egg and growth takes place as normal.

To date, as far as I personally know, all cloning of animals has followed this process.  Their are huge problems with this in terms of the life of the cloned animal.  Any genetic damage sustained in that adult DNA is replicated into EVERY SINGLE CELL of the new animal.  Attenuation, which is essentially the aging of DNA (google it) also poses a problem.  There are others as well that involve mitochondrial DNA and other things.  True solutions to these problems have yet to be found.  
 
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Wicked Chinchilla       6/2/2008 6:18:32 PM
**** Slight edit in my post above****

we CAN create DNA from scratch, but not in the sizes necessary to build a human genome or anything.  You can actually  design/request your own genetic primer for PCR and other such procedures.  You order it and you receive a little tube containing your primers.
 
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Herald12345       6/2/2008 7:05:10 PM

While I dont know of course about their black projects or if they even have black projects that are genetically oriented most of genetics is purely open source.  Since it started out as a pure science any discovery of note was published pretty quickly.  

As convoluted as genetics is the basic science behind it is rather straightforward.  Its a bit like chess: learning to play is one thing, becoming an expert is quite another.  Genetic manipulation of human DNA is possible now.  Unintended consequences and what happens behind these changes are what is unknown and harmful.  Right now all we can do is fumble with the building blocks.  We cannot create the DNA from scratch, the egg from scratch, grow the egg, etc.  As I said before with what genes actually govern, we have determined to an amazing extent what SOME genes do.  But we do not know what all genes do.  Nor do we know in how many processes they are all involved or their role in these processes.  Take a look at the genetic variants that predispose people to cancer for a taste of the complexity involved.  

What you might be wondering about also is cloning.  We have not figured out how to actually "clone" people or anything for that matter.  On the news when they speak of "cloning" goats or sheep or what not its not cloning as is pictured or talked about in movies.  It resembles artificial insemination more than movie cloning.  I read that article and the other cloning articles a good while ago so the details escape me.  However, my best description is that they take an egg from a female sheep then extract the DNA from it.  Adult DNA from the host sheep is then inserted into the egg.  The sheep is then inseminated with this egg and growth takes place as normal.

To date, as far as I personally know, all cloning of animals has followed this process.  Their are huge problems with this in terms of the life of the cloned animal.  Any genetic damage sustained in that adult DNA is replicated into EVERY SINGLE CELL of the new animal.  Attenuation, which is essentially the aging of DNA (google it) also poses a problem.  There are others as well that involve mitochondrial DNA and other things.  True solutions to these problems have yet to be found.  
I was wondering about the age effect in replicating the template animal. This is NOT an area in which I am comfortable as I don't know more than  the average layman..

What I understand is that the  genome  has a complex chemistry grammar that includes a lot of what we thought were "dead" sites but that these sites actually serve a placeholder function either for alleles that have switched off in our long chain of common descent or serve as "spacers" to keep the active sequences properly intervaled.

Like I said I'm a layman in this subject so I may have this all wrong, but just getting the intervals wrong or accidentally activating a sleeper  site could throw one of those sequences totally out of whack with unexpected consequences for the life-form growing or replicating. Or am I oversimplifying this and getting it fundamentally wrong to boot?

Herald
 
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00_Chem_AJB       6/2/2008 7:49:11 PM
As a chemist the complexity of DNA and proteins is nothing new to me, we are talking about molecules with a molar mass of 50Kg were are basically chemical programs thus there is alot of room for error, too much room in most people's opinion, but I get the feeling that research into this field is being stamped out here, infact many scientists are heading to the US. I understand the coation observed when releasing a product on the commercial market, but to kill off the research is a bad idea in my opinion. Like WC said a natural crop seemed to outclass the GM crop, however the possibility is that the GM crop will survive in conditions that would not susstain the natural crop, this is something we need to look at in the face of a changing environment. But we have been conducting genetic minipulation on an idustrial scale for over 50 years now, surely we know enough from all this experience some of the negative effects and are able to transplant this knoweldge when it comes to the GM crop industry and research. Appently GM crops require less fertilizers/insectasides/herb which should save money while lowering the ammount of chemicals released into the enviroment, something that might be helpful when one looks at the up coming EU legislation on the use of agro-chemicals.
 
As for nuclear power, I think it is because we are all scared shitless of another Chernobyl basically. But looking at this from a realistic point of view nuclear powerstations have a set lifespan of several decades, but really I think it could work as a stop gap untill we find a better way to meet our energy needs, the problem with "green" power at the moment is the lack of efficentcy, comapre the ammount of energy which the sun emmits on a sqaure metre of the Earth's surface and compare that to the ammount of electrcity produced by a current generation solar-eletric pannel and there really is a big defficet, this is being worked on however, but not in time to slove the current energy demands.
 
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