What Rocky said, plus ... Handloads just add one more thing your lawyer has to defend against if you do have to use your sidearm in self defense. In the event you have to use deadly force, it isn't an "if" you will be sued ... it's for how much. I say keep it simple and stick to good reputable premium loads from quality manufacturers. On specific suggestions; Gold dots are tough to beat. They tend to have a lower threshold for expansion than most other JHPs, which would make me think that out of a shorter tube there would be less lost performance. Cor-bon rounds are exceptional all the way around, and their 185 gr JHP+P would definitely be worth your while in testing out. Federal 230 gr Hydrashocks are my personal favorite .45 ACP load. That's really all I carry in a .45. Truthfully though, I don't use any.45s with anything shorter than a 4 1/4".
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