I think if I were wrong handed, I'd really consider something along the lines of the Glock, Springfield XD. The fewer controls you have to mess with, probably the better off you are. Other pistols do have ambidextrous features such as safeties and reversable mag releases. I'd handle as many different makes as you can, then decide which ones you can work with, or around, based on how they handle to you as an individual.

I concur with ChdNorm. The Glock-type pistols with "safe-action" triggers are fairly ambidextrous right out of the box. If you want something closer to a conventional DA auto, you might want to look at the Smith & Wesson SW 45, the .45 ACP member of the SW 99 family( they also maske them in 9m/m and .40 S&W). It's basically a Walther P99 with a better external shape for concealed carry (i.e., less sharp corners). It also sells for about the same price as the Glock or Springfield, most places, in any caliber..

By "wrong-handed" I assume you mean "sinestrous"? (Like my own self.) :-).