Anything is always possible. So i assume your question requests a more defined in-depth answer. Here is mine. Before and During the war, decisions were made (or not made) that determined the outcome of the war. So in order to change the out come (axis winning) anywhere from 1-all of the decisions that were made (or not made) must be altered in at least some way. It is not reasonable to say something like this: (...but if the weather would have been different...) because if history repeated itself, that same exact weather would occur in that area at that time again under control of nobody. It is reasonable to say (...if they would have launched that operation before that weather, or during, or after..ect..) which is a decision as stated above that would have to have been changed. Knowing this now we need to think of how many decisions, which ones, and how important were they. If you think about it, by changing the decisions made by the various troops, generals, and political figures of the war you can literally end up with almost an endless list of possible outcomes. I will not even try to state them all. Here are (inmy opinion) the most likely outcomes (where the axis wins)  and what "decisions" would have had to change in order for these to happen. I will divide these into Political, Economical/Technological, and Strategical subcategories.

     Politics- It is important to understand that the main reason hitler ordered less subs and more surface ships was to scare britian into submission, aswell as dunkirk to appease them and the half-hearted sub warfare to just scare them and not actually kill them is because hitler never wanted to conquer britian in his original plans. He enjoyed britian and its people, he viewed them as the only other pure, strong race. This also explains the lack of anphibious forces. Hitler tried very hard to get britian to either join him or back down. If this was not so, -if he would have planned the invasion as well as the rest of the invasion plans, britian would have fell. An underestimate of britians integrity and will caused the axis downfall. Britian ties down germany so they cant defeat soviets aswell as gives america an active platform for axis destruction.  

                 Others have stated this but i must rehiderate. Most of the soviet union, liked the soviet union less than the 3rd reich. If hitler wouldnt have been so oppressive and an evil fuck, he could have rallied the soviets agaisnt themselves, combined with germany's military dominance to that point, the soviets would have had internal wars/power struggles going on and a treaty would have been worked out just like in ww1. Instead hitler hated slavs and eastern europeans so he only excpeted a small limited army from the russian territories. If russia would have defeated itself due to germany, then germany could have focused on the west taking the mideast, and africa.

                 If the two decisions (by hitler) stated above would have been altered then despite whatever was going on in the paciffic, america would have had to settle with an agreement between them and germany at least.

                 Another thing i would like to mention is that roosevelts increasing strives to get into the war is what got us in , not exactly pearl harbor, (which by the way, we did know about before the attack hit) . But, if rossevelt "decided" not to rerun as president and somebody else took over who did not want to go to war, then the axis would have won for sure. I do not care what anybody says. Nobody was beating germany and certainly not japan without american help. And they wouldnt have lasted another 4 year election term eith